International Data Agrees (on Omicron variant, that it is less severe and natural immunity works) | Dr. John Campbell | Jan 13, 2022 (Video and Reference Data)

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Dr. John Campbell
24 min
Comprehensive Summary:


Omicron is less severe and natural immunity works
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Clinical outcomes among patients infected with Omicron (B.1.1.529) SARS-CoV-2 variant in southern California


The Omicron (B.1.1.529) variant of SARS-CoV-2 has rapidly achieved global dissemination,

accounting for most infections in the United States by December 2021.

November 30, 2021 to January 1, 2022, Delta v Omicron

Using S gene target failure (SGTF) (99.7%)

Hospital admission

Lengths of hospital stay

Hospital admissions associated with new-onset respiratory symptoms

Intensive care unit (ICU) admission

Mechanical ventilation


Group 1, omicron

N =  52,297, cases with Omicron variant infections

Hospital admissions, 235 (0.5%)

Mean follow-up, 5.5 days

88 admitted

ITU, 7

Ventilated, 0

Deaths, 1

Length of hospital stay, 3.4 days (70%) less than delta

Group 2, non – omicron (delta)

N = 16,982, cases with Delta variant infections

Hospital admissions, 222 (1.3%)

Mean follow-up, 15.8 days

189 admitted

ITU, 23

Ventilated, 11

Deaths, 14


Omicron variant infection, reduced risk of hospitalization across age and comorbidity categories

Risk of symptomatic hospitalization was markedly reduced among cases who had tested positive for SARS-CoV-2 infection ≥90 days prior

Intrinsically less severe infection

Less severe in vaccinated and unvaccinated

Evidence for a reduction in severe outcomes among vaccinated cases with both Delta and Omicron variant infections in our study suggests substantial public health benefits from continued COVID-19 vaccination.

Dutch data

Common cold protection

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts


Cross-reactive immune responses to SARS-CoV-2

52 COVID-19 household contacts

We enumerate the frequency of specific T cells

Spike, nucleocapsid, membrane, envelope and ORF1,

that cross-react with human endemic coronaviruses

Nucleocapsid-specific T cells

Limited protective function of spike-cross-reactive T cells

Our results are thus consistent with,

pre-existing non-spike cross-reactive memory T cells,

protecting SARS-CoV-2-naïve contacts from infection,

thereby supporting the inclusion of non-spike antigens in second-generation vaccines.



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