Self Tolerance and Microbe Triggered Autoimmunity – in T Cells and B Cells | Drbeen Medical Lectures | Dec 2021 (Videos)

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Drbeen Medical Lectures
Immunologic tolerance is defined as unresponsiveness to an antigen that is induced by exposure to that antigen. 
The term arose from the experimental observation that animals that had encountered an antigen under particular conditions would not respond to, that is, would tolerate, subsequent exposures to the same antigen.
 We have been discussing the autoantibodies or anti-idiotype antibodies for a few days.
A frequent question was that how does the immune system start attacking our own tissue while it was not doing so before the COVID infection or a Spike protein vaccine. 
Let’s build our understanding of these mechanisms.
Page 350. Anergy and the role of tissue resident dendritic cells.
Page 350. B cell tolerance. A beautiful mechanism of B cell receptor editing.
Page 351. B cell deletion by an unknown mechanism.
Normal mechanism is B cell anergy in the presence of abundant antigen from all sides of the immature B cell.

Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 337). Elsevier Health Sciences. Kindle Edition. 

Self Tolerance and Microbe Triggered Autoimmunity (T Cell Focus)    (1 hr, published on Dec 30, 2021)

Self Tolerance and Microbe Triggered Autoimmunity (B Cell Focus)    (28 min, published on Dec 31, 2021)

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Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

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